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COMLEX-USA Level 1

60 lessons across 15 topics

Topic 1: Comlex-usa Level 1 Exam Overview And The Two-axis Blueprint

1Lesson 1.1: Purpose, Pathway, And Decision Points2Lesson 1.2: Format, Timing, And Delivery (may 2026 Onward)3Lesson 1.3: Scoring, Pass/fail, And The Performance Profile4Lesson 1.4: Reading The Blueprint As A Study Map

Topic 2: Osteopathic Principles, Practice, And Manipulative Treatment (opp-omm)

5Lesson 2.1: Osteopathic Tenets And Philosophy6Lesson 2.2: Somatic Dysfunction Diagnosis And The Spine7Lesson 2.3: Omt Modalities And Indications8Lesson 2.4: Autonomic, Viscerosomatic, And Lymphatic Reasoning

Topic 3: Foundational Sciences I: Anatomy, Histology, And Embryology

9Lesson 3.1: Musculoskeletal And Back Anatomy10Lesson 3.2: Thorax, Abdomen, And Pelvis Anatomy11Lesson 3.3: Head, Neck, And Neuroanatomy12Lesson 3.4: Histology And Embryology

Topic 4: Foundational Sciences Ii: Physiology And Pathophysiology

13Lesson 4.1: Cardiovascular And Respiratory Physiology14Lesson 4.2: Renal, Fluid, And Electrolyte Physiology15Lesson 4.3: Gastrointestinal And Endocrine Physiology16Lesson 4.4: Neuromuscular And Integrative Physiology

Topic 5: Foundational Sciences Iii: Biochemistry, Genetics, And Cell Biology

17Lesson 5.1: Metabolism And Energy Pathways18Lesson 5.2: Molecular Biology And Nutrition19Lesson 5.3: Medical Genetics20Lesson 5.4: Cell Biology And General Pathology Mechanisms

Topic 6: Foundational Sciences Iv: Microbiology, Immunology, And Pharmacology

21Lesson 6.1: Bacteriology And Antibacterial Therapy22Lesson 6.2: Virology, Mycology, And Parasitology23Lesson 6.3: Immunology24Lesson 6.4: Principles Of Pharmacology And Toxicology

Topic 7: Behavioral Sciences, Population Health, And Medical Ethics

25Lesson 7.1: Behavioral Science And The Biopsychosocial Model26Lesson 7.2: Biostatistics And Epidemiology27Lesson 7.3: Patient Safety, Quality, And Systems-based Practice28Lesson 7.4: Medical Ethics, Professionalism, And Communication

Topic 8: Clinical Presentations I: Musculoskeletal And Integumentary Systems

29Lesson 8.1: Musculoskeletal Disorders And Osteopathic Correlation30Lesson 8.2: Connective Tissue And Autoimmune Rheumatologic Disease31Lesson 8.3: Integumentary Disorders32Lesson 8.4: Trauma, Pain, And Regional Musculoskeletal Complaints

Topic 9: Clinical Presentations Ii: Cardiovascular, Respiratory, And Hematologic Systems

33Lesson 9.1: Cardiovascular Disorders34Lesson 9.2: Respiratory Disorders35Lesson 9.3: Hematologic Disorders36Lesson 9.4: Integrated Cardiopulmonary And Hematologic Cases

Topic 10: Clinical Presentations Iii: Nervous System, Mental Health, And The Endocrine System

37Lesson 10.1: Neurologic Disorders38Lesson 10.2: Psychiatric And Behavioral Disorders39Lesson 10.3: Endocrine And Metabolic Disorders40Lesson 10.4: Integrated Neuroendocrine And Behavioral Cases

Topic 11: Clinical Presentations Iv: Gastrointestinal, Genitourinary, Reproductive, And Wellness

41Lesson 11.1: Gastrointestinal And Nutritional Disorders42Lesson 11.2: Genitourinary, Renal, And Breast Disorders43Lesson 11.3: Human Development, Reproduction, And Sexuality44Lesson 11.4: Community Health, Wellness, And Prevention

Topic 12: Item-type And Clinical-vignette Mastery

45Lesson 12.1: Anatomy Of A Single-best-answer Vignette46Lesson 12.2: Osteopathic And Integrated-science Item Patterns47Lesson 12.3: Audio-visual And Image-based Items48Lesson 12.4: Reasoning Strategies And Educated Guessing

Topic 13: Test-day Strategy, Pacing, And Stamina

49Lesson 13.1: Pacing Across Non-individually-timed Sections50Lesson 13.2: Forward-only Navigation And Within-section Review51Lesson 13.3: Break Strategy And Endurance52Lesson 13.4: Logistics, Rules, And The Day Before

Topic 14: Diagnostic Assessment And Blueprint-weighted Study Planning

53Lesson 14.1: Entry Diagnostic And Readiness Baseline54Lesson 14.2: Mapping Weaknesses To The Blueprint55Lesson 14.3: Building A Realistic Study Schedule56Lesson 14.4: Question Banks And Resource Integration

Topic 15: Full-length Simulation, Error Review, And Final Readiness

57Lesson 15.1: Full-length Timed Simulation58Lesson 15.2: Structured Error Review59Lesson 15.3: Spaced Re-testing And Knowledge Consolidation60Lesson 15.4: Final-week Protocol And Go/no-go Readiness