1. Foundations

Chemical Bonds — Quiz

Test your understanding of chemical bonds with 5 practice questions.

Practice Questions

Question 1

If the average energy of a covalent C–C bond is $350\,\mathrm{kJ/mol}$ and the average energy of a hydrogen bond is $20\,\mathrm{kJ/mol}$, approximately how many hydrogen bonds are required to equal the energy of one C–C bond?

Question 2

Given that burying one –CH$_2$– group contributes approximately $0.7\,\mathrm{kJ/mol}$ of stabilization, how many such methylene groups must be sequestered to match the energy of one hydrogen bond (~$20\,\mathrm{kJ/mol}$)?

Question 3

A leucine residue buried in the hydrophobic core of a globular protein is mutated to asparagine. What is the most likely effect on the protein’s stability and why?

Question 4

Why are disulfide bonds (–S–S–) prevalent in extracellular proteins but rare in the cytosolic environment?

Question 5

Which functional group in the protein backbone can act only as a hydrogen bond acceptor and never as a donor?