2. Molecular Biology

Genomic Integrity — Quiz

Test your understanding of genomic integrity with 5 practice questions.

Practice Questions

Question 1

Which specific DNA repair pathway is primarily responsible for correcting DNA damage that results in the formation of bulky adducts, such as those caused by benzo$a$pyrene?

Question 2

A patient presents with a genetic predisposition to certain cancers, including breast and ovarian cancer, due to a germline mutation in the BRCA1 gene. This gene is critically involved in which major DNA repair pathway?

Question 3

Consider a mutation that changes a codon from UGG (Tryptophan) to UGA (Stop). This type of point mutation is specifically classified as a:

Question 4

Genomic instability is a hallmark of cancer development. Which of the following molecular events is a direct consequence of genomic instability that fuels tumor evolution?

Question 5

The enzyme O⁶-methylguanine-DNA methyltransferase (MGMT) plays a critical role in directly reversing DNA damage caused by alkylating agents. This direct reversal mechanism is distinct from excision repair pathways because it: