1. Foundations of Immunology

Soluble Mediators — Quiz

Test your understanding of soluble mediators with 5 practice questions.

Practice Questions

Question 1

What is the primary STAT transcription factor activated by IL-6–driven JAK signaling in hepatocytes to induce acute phase protein gene expression?

Question 2

Given an IL-2 concentration of $10^{-9}$\,M and a receptor dissociation constant $K_D$ of $10^{-10}$\,M, what fraction of IL-2 receptors is occupied?

Question 3

A patient receiving eculizumab, an anti-C5 monoclonal antibody, has impaired complement function leading to increased susceptibility to Neisseria infections. Which complement function is directly inhibited by eculizumab?

Question 4

In the alternative complement pathway, the spontaneous hydrolysis of C3, termed “tick-over,” generates C3(\!H_2O). Which complement protein then binds C3(\!H_2O) to form the fluid-phase C3 convertase?

Question 5

During mannose-binding lectin (MBL) pathway activation, MBL–associated serine protease 2 (MASP-2) cleaves which complement components to form the C3 convertase?