2. Genetics

Mutation Mechanisms — Quiz

Test your understanding of mutation mechanisms with 5 practice questions.

Practice Questions

Question 1

Which enzyme activity of DNA polymerase is responsible for removing misincorporated nucleotides in the 3′→5′ direction during replication to reduce mutation rates?

Question 2

Which protein kinase is primarily activated by single-stranded DNA at stalled replication forks to initiate the intra-S phase checkpoint in eukaryotic cells?

Question 3

In translesion DNA synthesis (TLS), which specialized polymerase primarily functions in the extension step past a DNA lesion after nucleotide insertion?

Question 4

What is the principal advantage of translesion DNA synthesis (TLS) for cells experiencing persistent DNA lesions?

Question 5

Which enzyme initiates somatic hypermutation in immunoglobulin genes by deaminating cytosine to uracil in single-stranded DNA?