2. Genetics

Population Genetics — Quiz

Test your understanding of population genetics with 5 practice questions.

Practice Questions

Question 1

Under haploid selection with selection coefficient $s=0.1$ acting against allele $a$, in a population where allele $A$ has frequency $p=0.6$ and allele $a$ has frequency $q=0.4$, what is the change in allele frequency $\Delta p$ in one generation? Show your calculation.

Question 2

If the inbreeding coefficient is $F=0.2$ and allele frequencies are $p=0.7$ and $q=0.3$, what is the expected observed heterozygote frequency $H_{obs}$? Show your calculation.

Question 3

Which dN/dS ratio value is indicative of purifying (negative) selection acting on protein-coding genes?

Question 4

In a population with allele frequency $p=0.2$, migrants comprising 10\\% of the population introduce a migrant allele frequency of $p_m=0.8$. What is the new allele frequency $p'$ after migration? Show your calculation.

Question 5

Two species' homologous DNA sequences exhibit an average divergence of 0.12 substitutions per site. Assuming a molecular clock rate of $1.5\times10^{-9}$ substitutions per site per year, what is the estimated divergence time? Show your calculation.