4. RNA Biology

Noncoding Rnas — Quiz

Test your understanding of noncoding rnas with 5 practice questions.

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Practice Questions

Question 1

Which domain of the Argonaute protein binds the 3′ end of a guide microRNA to facilitate target recognition?

Question 2

A loss-of-function mutation in Dicer would primarily disrupt which classes of noncoding RNAs?

Question 3

The long noncoding RNA HOTAIR silences gene expression by acting as a scaffold for which chromatin-modifying complex?

Question 4

Which long noncoding RNA is essential for the formation and structural integrity of nuclear paraspeckles?

Question 5

A microRNA binds its target site with a dissociation constant $K_d=10\;\mathrm{nM}$. If intracellular microRNA concentration is 30\;nM, what fraction of target sites is occupied at equilibrium?