1. Foundations of Nursing

Clinical Reasoning — Quiz

Test your understanding of clinical reasoning with 5 practice questions.

Practice Questions

Question 1

What is the primary function of the Mediator complex in eukaryotic transcription initiation?

Question 2

Which general transcription factor of RNA Polymerase II phosphorylates Ser5 of the CTD heptapeptide repeat, triggering promoter clearance and recruiting capping enzymes?

Question 3

In a prokaryotic intrinsic terminator, deletion of the U-rich tract downstream of the GC-rich hairpin will most likely result in which outcome?

Question 4

A point mutation in the σ70 region 2 helix-turn-helix motif changes a lysine residue that contacts the –10 element to glutamate. What effect would this have on transcription in E. coli?

Question 5

A eukaryotic gene of 12,000 nucleotides is transcribed at an average RNAP II elongation rate of 50 nt/s with 10 pause sites lasting 5 s each. Calculate the approximate time required for transcription. Show your calculation.