5. Therapeutics and Pharmacology
Drug Delivery — Quiz
Test your understanding of drug delivery with 5 practice questions.
Practice Questions
Question 1
Which anatomical barrier most significantly limits the penetration of topically applied drugs to the posterior segment of the eye?
Question 2
Consider a drug with a half-life of 2 hours that needs to maintain a therapeutic concentration in the vitreous for 3 months. A single intravitreal injection sustains therapeutic levels for 24 hours. Approximately how many injections would be required over 3 months without a sustained-release system?
Question 3
If each intravitreal injection carries a 0.05 % risk of endophthalmitis, what is the cumulative risk after 10 independent injections?
Question 4
Given a corneal permeability coefficient $P=5\times10^{-6}\,\mathrm{cm/s}$ and a constant tear film concentration $C=2\,\mathrm{mg/mL}$ (1 mL=1 cm³), what is the flux $J$ in $\mathrm{mg/cm^2/s}$?
Question 5
What is a primary advantage of a biodegradable sustained-release ocular implant over a non-biodegradable one?