1. Foundational Sciences

Biochemistry — Quiz

Test your understanding of biochemistry with 5 practice questions.

Practice Questions

Question 1

Given two cyclooxygenase isozymes have $k_{cat1}=10\ \mathrm{s^{-1}},\ K_{M1}=5\ \mu\mathrm{M}$ and $k_{cat2}=15\ \mathrm{s^{-1}},\ K_{M2}=30\ \mu\mathrm{M}$, which isozyme exhibits greater catalytic efficiency?

Question 2

Glucokinase in hepatocytes has a high $K_M$ (~10 mM) for glucose. What is the physiological significance of this kinetic property?

Question 3

A Lineweaver–Burk plot of an enzyme in the presence and absence of an inhibitor shows parallel lines (identical slopes). This indicates which type of inhibition?

Question 4

A drug with intrinsic hepatic clearance (CL_{int}) of 30 L/h and hepatic blood flow $Q_h$ of 90 L/h follows the well‐stirred model. What is its hepatic extraction ratio $E_H$?

Question 5

Which Phase II drug metabolism reaction uses UDP‐glucuronic acid as a cofactor and is catalyzed by UGT enzymes?