2. Pharmaceutical Chemistry

Pharmaceutical Analysis — Quiz

Test your understanding of pharmaceutical analysis with 5 practice questions.

Practice Questions

Question 1

In HPLC, the tailing factor (T) at 5% peak height is given by $T=\frac{W_{0.05}}{2f}$ where $W_{0.05}$ is the peak width at 5% height and $f$ is the distance from the peak maximum to the leading edge at 5% height. If $W_{0.05}=0.20\,$min and $f=0.05\,$min, what is the tailing factor?

Question 2

Which technique is used to assess matrix effects, such as ion suppression, in LC-MS analyses?

Question 3

In UV-Vis spectrophotometry with a 1\,cm pathlength cell and molar absorptivity $\varepsilon=15\,000\,\mathrm{L\,mol^{-1}\,cm^{-1}}$, the instrument’s linear absorbance range is 0.10–1.00\,AU. What is the corresponding linear concentration range in mol/L?

Question 4

Which detection principle is employed by the light obscuration method for particulate matter in injectable solutions?

Question 5

Baseline drift in an HPLC UV detector caused by dissolved gas bubbles is best minimized by which action?