2. Pharmaceutical Chemistry

Physical Chemistry — Quiz

Test your understanding of physical chemistry with 5 practice questions.

Practice Questions

Question 1

Given a weak acid HA with pKa=7.4 and partition coefficient P such that log P=2.0, what is its approximate log D at pH 9.4?

Question 2

If the solubility of a drug in water doubles when temperature increases from 25°C to 45°C, what is the approximate enthalpy of solution ΔH_sol? (Assume van ’t Hoff behavior.)

Question 3

Which sign of enthalpy change ΔH characterizes the dissolution of a gas in a liquid?

Question 4

In a binary solution where the mole fraction of solvent is 0.75 and the pure solvent vapor pressure is 160 mmHg, what is the vapor pressure lowering ΔP according to Raoult’s law?

Question 5

At constant temperature and volume, which thermodynamic potential determines spontaneity of a process?