2. Pharmaceutical Chemistry

Medicinal Chemistry — Quiz

Test your understanding of medicinal chemistry with 5 practice questions.

Practice Questions

Question 1

Which metric normalizes the binding affinity of a compound to its molecular size during lead optimization?

Question 2

For two analogs with inhibition constants Ki of 10 nM (Analog A) and 100 nM (Analog B), what is the difference in binding free energy ΔΔG at 298 K?

Question 3

In structure–activity relationship studies, introducing a para methyl group on a phenyl ring most commonly affects potency by which mechanism?

Question 4

Which functional group substitution represents a classical bioisosteric replacement for a peptide amide bond to modulate metabolic stability?

Question 5

Why are phosphate prodrugs commonly used for phenolic drugs in oral formulations?