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USMLE Step 1

67 lessons across 16 topics

Topic 1: Exam Overview, Blueprint, And Strategy

1Lesson 1.1: The Usmle Sequence And The Purpose Of Step 12Lesson 1.2: The Step 1 Content Blueprint3Lesson 1.3: Format, Timing, And Pass/fail Scoring4Lesson 1.4: Building A Study Plan And Resource Strategy

Topic 2: General Principles: Cell And Molecular Biology, Biochemistry, And Genetics

5Lesson 2.1: Cell Structure, Signaling, And The Cell Cycle6Lesson 2.2: Biochemistry And Metabolic Pathways7Lesson 2.3: Molecular Biology And Gene Expression8Lesson 2.4: Medical Genetics And Inheritance

Topic 3: General Principles: Microbiology, Immunology, And Pharmacology Foundations

9Lesson 3.1: Microbial Classification And Pathogenesis10Lesson 3.2: Antimicrobial Pharmacology And Resistance11Lesson 3.3: Innate And Adaptive Immunity12Lesson 3.4: Hypersensitivity, Immunodeficiency, And Autoimmunity13Lesson 3.5: Principles Of Pharmacokinetics, Pharmacodynamics, And Toxicology

Topic 4: General Principles: Pathology, Inflammation, And Neoplasia

14Lesson 4.1: Cellular Injury, Adaptation, And Cell Death15Lesson 4.2: Acute And Chronic Inflammation And Repair16Lesson 4.3: Hemodynamic Disorders17Lesson 4.4: Neoplasia And Cancer Biology

Topic 5: Behavioral Sciences, Nervous System, And Special Senses

18Lesson 5.1: Neuroanatomy, Neurophysiology, And Lesion Localization19Lesson 5.2: Neuropathology20Lesson 5.3: Psychiatry And Behavioral Health21Lesson 5.4: Neuropharmacology And Psychopharmacology22Lesson 5.5: Special Senses

Topic 6: Cardiovascular System

23Lesson 6.1: Cardiac Anatomy, Embryology, And Physiology24Lesson 6.2: Vascular Physiology And Hemodynamics25Lesson 6.3: Cardiovascular Pathology26Lesson 6.4: Cardiovascular Pharmacology

Topic 7: Respiratory System

27Lesson 7.1: Respiratory Anatomy, Embryology, And Mechanics28Lesson 7.2: Gas Exchange And Acid-base Physiology29Lesson 7.3: Respiratory Pathology30Lesson 7.4: Respiratory Pharmacology

Topic 8: Renal And Urinary System

31Lesson 8.1: Renal Anatomy, Embryology, And Physiology32Lesson 8.2: Fluid, Electrolyte, And Acid-base Regulation33Lesson 8.3: Renal And Urinary Pathology34Lesson 8.4: Renal Pharmacology

Topic 9: Gastrointestinal System And Nutrition

35Lesson 9.1: Gi And Hepatobiliary Anatomy And Embryology36Lesson 9.2: Digestive Physiology37Lesson 9.3: Gastrointestinal And Hepatic Pathology38Lesson 9.4: Gi Pharmacology And Clinical Nutrition

Topic 10: Reproductive And Endocrine Systems

39Lesson 10.1: Endocrine Physiology And Hormonal Regulation40Lesson 10.2: Endocrine Pathology And Pharmacology41Lesson 10.3: Reproductive Anatomy, Embryology, And Physiology42Lesson 10.4: Reproductive Pathology And Pharmacology

Topic 11: Hematology, Lymphoreticular, And Immune Systems

43Lesson 11.1: Hematopoiesis And Blood Cell Physiology44Lesson 11.2: Anemias And Red Cell Disorders45Lesson 11.3: Hemostasis, Coagulation, And Bleeding Disorders46Lesson 11.4: White Cell, Lymphoreticular Pathology, And Hematologic Pharmacology

Topic 12: Musculoskeletal System, Skin, And Subcutaneous Tissue

47Lesson 12.1: Musculoskeletal Anatomy And Physiology48Lesson 12.2: Musculoskeletal Pathology49Lesson 12.3: Dermatology: Structure, Pathology, And Pharmacology50Lesson 12.4: Rheumatology And Connective Tissue Disease

Topic 13: Multisystem Processes, Biostatistics, Epidemiology, And Health Systems

51Lesson 13.1: Multisystem And Systemic Disorders52Lesson 13.2: Human Development And Aging53Lesson 13.3: Biostatistics And Quantitative Reasoning54Lesson 13.4: Epidemiology And Study Design55Lesson 13.5: Health Systems, Quality, And Safety

Topic 14: Communication, Ethics, And Professionalism

56Lesson 14.1: Medical Ethics And Professionalism57Lesson 14.2: Informed Consent, Capacity, And Confidentiality58Lesson 14.3: Patient Communication And Difficult Conversations59Lesson 14.4: Scenario-based Judgment Items

Topic 15: Item-type And Case-format Mastery

60Lesson 15.1: Anatomy Of A Single-best-answer Vignette61Lesson 15.2: Interpreting Data, Labs, And Media62Lesson 15.3: Distractor Analysis And Answer Selection63Lesson 15.4: Cross-discipline And Integrated Items

Topic 16: Test-day Readiness, Pacing, And Full-length Practice

64Lesson 16.1: Pacing Within And Across Blocks65Lesson 16.2: Break Management And Stamina66Lesson 16.3: Test Anxiety And Performance Psychology67Lesson 16.4: Full-length Simulation And Final Review